This application report provides design guidelines for the CC13xx/CC26xx SimpleLink™ ultra-low-power wireless MCU platform. There is an overview of the different reference designs followed by RF front-end, schematic, PCB, and antenna design considerations. The document also covers crystal oscillator tuning, optimum load impedance as well as a brief explanation of the different power supply configurations. The last section of the document provides a summary of steps to carry out at board bring-up.